“Most research in physics is continuations of things that have gone before,” said Wilczek, a professor at the Massachusetts Institute of Technology. This, he said, was “kind of outside the box.”

Wilczek’s idea met with a muted response from physicists. Here was a brilliant professor known for developing exotic theories that later entered the mainstream, including the existence of particles called axions and anyons, and discovering a property of nuclear forces known as asymptotic freedom (for which he shared the Nobel Prize in physics in 2004). But perpetual motion, deemed impossible by the fundamental laws of physics, was hard to swallow. Did the work constitute a major breakthrough or faulty logic? Jakub Zakrzewski, a professor of physics and head of atomic optics at Jagiellonian University in Poland who wrote a perspective on the research that accompanied Wilczek’s publication, says: “I simply don’t know.”

Now, a technological advance has made it possible for physicists to test the idea. They plan to build a time crystal, not in the hope that this perpetuum mobile will generate an endless supply of energy (as inventors have striven in vain to do for more than a thousand years) but that it will yield a better theory of time itself. Continue, Simons Foundation

It turns out that they do, sort of, and a NASA-funded researcher at the University of Iowa has figured out how to find them.

“We call them X-points or electron diffusion regions,” explains plasma physicist Jack Scudder of the University of Iowa. “They’re places where the magnetic field of Earth connects to the magnetic field of the Sun, creating an uninterrupted path leading from our own planet to the sun’s atmosphere 93 million miles away.”

Observations by NASA’s THEMIS spacecraft and Europe’s Cluster probes suggest that these magnetic portals open and close dozens of times each day. They’re typically located a few tens of thousands of kilometers from Earth where the geomagnetic field meets the onrushing solar wind. Most portals are small and short-lived; others are yawning, vast, and sustained. Tons of energetic particles can flow through the openings, heating Earth’s upper atmosphere, sparking geomagnetic storms, and igniting bright polar auroras.

NASA is planning a mission called “MMS,” short for Magnetospheric Multiscale Mission, due to launch in 2014, to study the phenomenon. Bristling with energetic particle detectors and magnetic sensors, the four spacecraft of MMS will spread out in Earth’s magnetosphere and surround the portals to observe how they work.

Just one problem: Finding them. Magnetic portals are invisible, unstable, and elusive. They open and close without warning “and there are no signposts to guide us in,” notes Scudder.

Actually, there are signposts, and Scudder has found them.

Portals form via the process of magnetic reconnection. Mingling lines of magnetic force from the sun and Earth criss-cross and join to create the openings. “X-points” are where the criss-cross takes place. The sudden joining of magnetic fields can propel jets of charged particles from the X-point, creating an “electron diffusion region.”

To learn how to pinpoint these events, Scudder looked at data from a space probe that orbited Earth more than 10 years ago.

“In the late 1990s, NASA’s Polar spacecraft spent years in Earth’s magnetosphere,” explains Scudder, “and it encountered many X-points during its mission.”

Because Polar carried sensors similar to those of MMS, Scudder decided to see how an X-point looked to Polar. “Using Polar data, we have found five simple combinations of magnetic field and energetic particle measurements that tell us when we’ve come across an X-point or an electron diffusion region. A single spacecraft, properly instrumented, can make these measurements.”

This means that single member of the MMS constellation using the diagnostics can find a portal and alert other members of the constellation. Mission planners long thought that MMS might have to spend a year or so learning to find portals before it could study them. Scudder’s work short cuts the process, allowing MMS to get to work without delay.

It’s a shortcut worthy of the best portals of fiction, only this time the portals are real. And with the new “signposts” we know how to find them. Link to video: Nasa

In a study published early online on Sunday, January 8, in Nature, a team of scientists from the University of Chicago and the University of Oregon demonstrate how just a few small, high-probability mutations increased the complexity of a molecular machine more than 800 million years ago. By biochemically resurrecting ancient genes and testing their functions in modern organisms, the researchers showed that a new component was incorporated into the machine due to selective losses of function rather than the sudden appearance of new capabilities.

“Our strategy was to use ‘molecular time travel’ to reconstruct and experimentally characterize all the proteins in this molecular machine just before and after it increased in complexity,” said the study’s senior author Joe Thornton, PhD, professor of human genetics and evolution & ecology at the University of Chicago, professor of biology at the University of Oregon, and an Early Career Scientist of the Howard Hughes Medical Institute.

“By reconstructing the machine’s components as they existed in the deep past,” Thornton said, “we were able to establish exactly how each protein’s function changed over time and identify the specific genetic mutations that caused the machine to become more elaborate.”

The study – a collaboration of Thornton’s molecular evolution laboratory with the biochemistry research group of the UO’s Tom Stevens, professor of chemistry and member of the Institute of Molecular Biology – focused on a molecular complex called the V-ATPase proton pump, which helps maintain the proper acidity of compartments within the cell.

One of the pump’s major components is a ring that transports hydrogen ions across membranes. In most species, the ring is made up of a total of six copies of two different proteins, but in fungi a third type of protein has been incorporated into the complex.

To understand how the ring increased in complexity, Thornton and his colleagues “resurrected” the ancestral versions of the ring proteins just before and just after the third subunit was incorporated. To do this, the researchers used a large cluster of computers to analyze the gene sequences of 139 modern-day ring proteins, tracing evolution backwards through time along the Tree of Life to identify the most likely ancestral sequences. They then used biochemical methods to synthesize those ancient genes and express them in modern yeast cells.

Thornton’s research group has helped to pioneer this molecular time-travel approach for single genes; this is the first time it has been applied to all the components in a molecular machine.

The group found that the third component of the ring in Fungi originated when a gene coding for one of the subunits of the older two-protein ring was duplicated, and the daughter genes then diverged on their own evolutionary paths.

The pre-duplication ancestor turned out to be more versatile than either of its descendants: expressing the ancestral gene rescued modern yeast that otherwise failed to grow because either or both of the descendant ring protein genes had been deleted. In contrast, each resurrected gene from after the duplication could only compensate for the loss of a single ring protein gene.

The researchers concluded that the functions of the ancestral protein were partitioned among the duplicate copies, and the increase in complexity was due to complementary loss of ancestral functions rather than gaining new ones. By cleverly engineering a set of ancestral proteins fused to each other in specific orientations, the group showed that the duplicated proteins lost their capacity to interact with some of the other ring proteins. Whereas the pre-duplication ancestor could occupy five of the six possible positions within the ring, each duplicate gene lost the capacity to fill some of the slots occupied by the other, so both became obligate components for the complex to assemble and function.

“It’s counterintuitive but simple: complexity increased because protein functions were lost, not gained,” Thornton said. “Just as in society, complexity increases when individuals and institutions forget how to be generalists and come to depend on specialists with increasingly narrow capacities.”

The research team’s last goal was to identify the specific genetic mutations that caused the post-duplication descendants to functionally degenerate. By reintroducing historical mutations that occurred after the duplication into the ancestral protein, they found that it took only a single mutation from each of the two lineages to destroy the same specific functions and trigger the requirement for a three-protein ring.

“The mechanisms for this increase in complexity are incredibly simple, common occurrences,” Thornton said. “Gene duplications happen frequently in cells, and it’s easy for errors in copying to DNA to knock out a protein’s ability to interact with certain partners. It’s not as if evolution needed to happen upon some special combination of 100 mutations that created some complicated new function.”

Thornton proposes that the accumulation of simple, degenerative changes over long periods of times could have created many of the complex molecular machines present in organisms today. Such a mechanism argues against the intelligent design concept of “irreducible complexity,” the claim that molecular machines are too complicated to have formed stepwise through evolution.

“I expect that when more studies like this are done, a similar dynamic will be observed for the evolution of many molecular complexes,” Thornton said.

“These really aren’t like precision-engineered machines at all,” he added. “They’re groups of molecules that happen to stick to each other, cobbled together during evolution by tinkering, degradation, and good luck, and preserved because they helped our ancestors to survive.”

Source: University of Chicago Medical Center [January 08, 2012]